The effects of creatine supplementation with and without an Extract of Artemisia dracunculus on resistance training adaptations: preliminary findings

Background Co-ingesting creatine (5 g) with large amounts of glucose (e.g., 95 g) has been shown to enhance creatine and carbohydrate storage in muscle. It has been speculated that creatine transport is mediated in part by glucose and insulin. The increases in creatine retention are accompanied by an undesired caloric load and as a result, additional research has been undertaken to assess the effect of co-ingesting creatine with nutrients that may enhance insulin sensitivity. Co-ingestion of creatine (Cr) with an antihyperglycemic extract of Artemisia dracunculus (Russian tarragon (RT)), has been shown to influence plasma Cr levels comparable to co-ingestion of Cr and glucose [1]. However, other research has shown that short term (5 days) co-ingestion of Cr and RT (Cr+RT) did not enhance whole body creatine retention or muscle free creatine content [2]. The purpose of this on-going investigation was to compare the long-term effects of resistance training in combination with either Cr+RT, or Cr with carbohydrate (Cr+CHO), or carbohydrate (PL) ingestion.